Neuronal inhibition of the autophagy nucleation complex extends lifespan in post-reproductive C. elegans Authors
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چکیده
Affiliations 1Laboratory of Molecular Epigenetics, Institute of Molecular Biology (IMB), Mainz, Germany, Ackermannweg 4, 55128 Mainz, Germany 2Faculty of Biology, Johannes Gutenberg University, 55099 Mainz, Germany 3Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center (MDC), RobertRössle-Straße 10, 13125 Berlin, Germany *Correspondence to: [email protected] †These authors contributed equally
منابع مشابه
Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans.
Autophagy is a ubiquitous catabolic process that causes cellular bulk degradation of cytoplasmic components and is generally associated with positive effects on health and longevity. Inactivation of autophagy has been linked with detrimental effects on cells and organisms. The antagonistic pleiotropy theory postulates that some fitness-promoting genes during youth are harmful during aging. On t...
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تاریخ انتشار 2017